Voltage-gated potassium channel Kv1. 3 as a target in therapy of cancer
A Teisseyre, A Palko-Labuz, K Sroda-Pomianek… - Frontiers in …, 2019 - frontiersin.org
Voltage-gated potassium channel Kv1. 3 is an integral membrane protein, which is
selectively permeable for potassium ions and is activated upon a change of membrane …
selectively permeable for potassium ions and is activated upon a change of membrane …
Voltage-gated potassium channels as regulators of cell death
Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …
Single‐cell damage elicits regional, nematode‐restricting ethylene responses in roots
Plants are exposed to cellular damage by mechanical stresses, herbivore feeding, or
invading microbes. Primary wound responses are communicated to neighboring and distal …
invading microbes. Primary wound responses are communicated to neighboring and distal …
Unique molecular characteristics and microglial origin of Kv1. 3 channel–positive brain myeloid cells in Alzheimer's disease
Kv1. 3 potassium channels, expressed by proinflammatory central nervous system
mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating …
mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating …
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges
Š Gubič, LA Hendrickx, Ž Toplak… - Medicinal research …, 2021 - Wiley Online Library
Abstract The KV1. 3 voltage‐gated potassium ion channel is involved in many physiological
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …
Potassium channels: Novel targets for tumor diagnosis and chemoresistance
M Li, P Tian, Q Zhao, X Ma, Y Zhang - Frontiers in Oncology, 2023 - frontiersin.org
In recent years, the role of potassium channels in tumors has been intensively studied.
Potassium channel proteins are widely involved in various physiological and pathological …
Potassium channel proteins are widely involved in various physiological and pathological …
Kv1.3 K+ Channel Physiology Assessed by Genetic and Pharmacological Modulation
T Varanita, B Angi, V Scattolini, I Szabo - Physiology, 2023 - journals.physiology.org
Potassium channels are widespread over all kingdoms and play an important role in the
maintenance of cellular ionic homeostasis. Kv1. 3 is a voltage-gated potassium channel of …
maintenance of cellular ionic homeostasis. Kv1. 3 is a voltage-gated potassium channel of …
The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation
R Immler, W Nadolni, A Bertsch, V Morikis… - Cardiovascular …, 2022 - academic.oup.com
Aims Neutrophil trafficking within the vasculature strongly relies on intracellular calcium
signalling. Sustained Ca2+ influx into the cell requires a compensatory efflux of potassium to …
signalling. Sustained Ca2+ influx into the cell requires a compensatory efflux of potassium to …
How the potassium channel response of T lymphocytes to the tumor microenvironment shapes antitumor immunity
M Chirra, HS Newton, VS Gawali, TM Wise-Draper… - Cancers, 2022 - mdpi.com
Simple Summary Ion channels are proteins that control the movement of ions across the
membranes of cells, thus regulating their physiological functions. In T lymphocytes, ion …
membranes of cells, thus regulating their physiological functions. In T lymphocytes, ion …
Ion channels as new attractive targets to improve re-myelination processes in the brain
F Cherchi, I Bulli, M Venturini, AM Pugliese… - International journal of …, 2021 - mdpi.com
Multiple sclerosis (MS) is the most demyelinating disease of the central nervous system
(CNS) characterized by neuroinflammation. Oligodendrocyte progenitor cells (OPCs) are …
(CNS) characterized by neuroinflammation. Oligodendrocyte progenitor cells (OPCs) are …