The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Diabetic foot is a severe public health issue, yet rare studies investigated its global
epidemiology. Here we performed a systematic review and meta-analysis through searching …

Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

In 2005, it was estimated that more than 20 million people in the United States had diabetes.
Approximately 30% of these people had undiagnosed cases. Increased risk for diabetes is …

Background Cardiovascular morbidity is a major burden in patients with type 2 diabetes. In
the Steno-2 Study, we compared the effect of a targeted, intensified, multifactorial …

Metformin (dimethylbiguanide) is an orally administered drug used to lower blood glucose
concentrations in patients with non-insulin-dependent diabetes mellitus (NIDDM). 1 It …

This statement examines the cardiovascular complications of diabetes mellitus and
considers opportunities for their prevention. These complications include coronary heart …

ContextKidney disease in type 2 diabetes mellitus (DM) is more heterogeneous than in type
1 DM. Reduced glomerular filtration rate (GFR) among individuals with type 2 DM may not …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

In the not-so-distant past, type 2 diabetes mellitus was thought to be a relatively benign
condition, at least in the elderly, with relatively little effect on life expectancy or renal function …