Development of low-cost in-house tetra-ARMS-PCR assay for the screening of five CBS mutations found in Pakistani homocystinuria patients

A Khalil, HN Khan, M Wasim, H Ayesha… - … , Nucleotides & Nucleic …, 2024 - Taylor & Francis
Background Classical homocystinuria is an inborn amino acid metabolism disorder resulting
from mutations in the Cystathionine-β-Synthase (CBS) gene. These mutations lead to …

Stability‐Indicating RP‐HPLC Method for Lopinavir Estimation in Pharmaceutical Co‐Crystals: A Design of Expert Approach

P Mehta, BR Sharannavar, R Koli - Separation Science Plus, 2024 - Wiley Online Library
The primary objective of this investigation was to develop and validate a robust reversed‐
phase high‐performance liquid chromatography (RP‐HPLC) method for the quantification of …

[HTML][HTML] Initiating Newborn Screening for Metabolic Disorders in Pakistan: A Qualitative Study of the Early Challenges and Opportunities

M Wasim, HN Khan, H Ayesha, FR Awan - Rare, 2023 - Elsevier
In multiple countries, newborn screening (NBS) initiatives have provided prevalence insights
for inborn errors of metabolism (IEM), but Pakistan lacks such data. Few reports exist on IEM …

Spectrophotometric Study of Excitatory Amino Acids with Ortho-Phthalaldehyde

S Baloch, S Ashraf, W Durani, RZ Durani - Journal of Health and …, 2024 - jhrlmc.com
Background: Understanding the concentration of amino acids in biological samples is
pivotal for numerous biochemical and clinical studies. Aspartic acid and glutamic acid, being …