This paper reviews how active research in West Bengal has unmasked the endemic
arsenism that has detrimental effects on the health of millions of people and their offspring. It …

Over a century ago, Theodor Boveri paved the way to mechanistic studies linking
chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical …

A marker strongly associated with outcome (or disease) is often assumed to be effective for
classifying persons according to their current or future outcome. However, for this …

The objective of this state of the art paper is to review the mechanisms of induction, the fate,
the methodology, the sensitivity/specificity and predictivity of two major cytogenetic …

An increased risk of cancer in healthy individuals with high levels of chromosomal
aberrations (CAs) in peripheral blood lymphocytes has been described in recent …

Previous studies have suggested that the frequency of chromosomal aberrations (CAs), but
not of sister chromatid exchanges (SCEs), predicts cancer risk. We have further examined …

Cytogenetic biomarkers have long been applied in surveillance of human genotoxic
exposure and early effects of genotoxic carcinogens. Due to their wide use, it has been …

Arsenic (As) is a ubiquitous element. The current WHO guideline for As in drinking water is
10μg/L. Furthermore, about 130 million people have only access to drinking water …

Cytogenetic biomarkers are by far the most frequently used endpoints in human population
studies. Their sensitivity for measuring exposure to genotoxic agents and their role as early …

Arsenic is widely distributed in nature in air, water and soil in the form of either metalloids or
chemical compounds. It is used commercially, as pesticide, wood preservative, in the …