The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

The occurrence of protein mediated lipid transfer between intracellular membranes has
been known since the late 1960's. Since these early discoveries, numerous proteins …

Mutations in the human VPS13 genes are responsible for neurodevelopmental and
neurodegenerative disorders including chorea acanthocytosis (VPS13A) and Parkinson's …

Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …

An enigmatic step in de novo formation of the autophagosome membrane compartment is
the expansion of the precursor membrane phagophore, which requires the acquisition of …

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic cystic neoplasm
that is often invasive and metastatic, resulting in a poor prognosis. Few molecular alterations …

Upon starvation, cells rewire their metabolism, switching from glucose-based metabolism to
mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets …

Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose
tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine …

Autophagy is an enigmatic cellular process in which double-membrane compartments,
called “autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and …