Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Objectives Burnout is a state of exhaustion resulting from prolonged and excessive
workplace stress. We sought to examine biological underpinnings of burnout, focussing on …

In contrast to traditional perspectives of resilience as a stable, trait-like characteristic,
resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long …

Despite that burnout presents a serious burden for modern society, there are no diagnostic
criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there …

Gene-by-environment interactions (G× Es) can provide important biological insights into
psychiatric disorders and may consequently have direct clinical implications. In this review …

Health care has changed since the decline in mortality caused by infectious diseases as
well as chronic and non-contagious diseases, with a direct impact on the cost of public …

Stress plays an important role in major depressive disorder (MDD) and is one of the state
dependent factors in suicidal behavior. A dysfunctional hypothalamic-pituitary-adrenal axis …

Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the
dysfunction of prefrontal dopamine has been associated with cognitive and emotional …

Perinatal stress mediated through the mother can lead to long-term alterations in stress-
related phenotypes in offspring. The capacity for adaptation to adversity in early life depends …

Early childhood experiences have lasting effects on development, including the risk for
psychiatric disorders. Research examining the biologic underpinnings of these associations …