Cancer is a major public health problem worldwide. Gastrointestinal cancers account for
approximately one-third of the total global cancer incidence and mortality. Historically, the …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the
course of the development of fibrosis, certain parts of the intestine become narrowed …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases, characterized
by a treatment-resistant and invasive nature. In line with these inherent aggressive …

The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses
infection by Gram-negative bacteria, including Salmonella Typhimurium (S. Tm) and …

Intestinal fibrosis is an inevitable complication in patients with inflammatory bowel disease
[IBD], occurring in its two major clinical manifestations: ulcerative colitis and Crohn's …

The introduction of biologics such as anti-tumor necrosis factor (TNF) monoclonal antibodies
followed by anti-integrins has dramatically changed the therapeutic paradigm of …

Organoid is a cell organization grown in a three‐dimensional (3D) culture system which
represents all characteristics of its origin. However, this organ‐like structure requires …

In recent years, the advent of intestinal organoid culture systems has revolutionized in vitro
studies of the small intestine epithelium. Intestinal organoids are derived from self …