Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

Signalling by the Wnt family of secreted lipoproteins has essential functions in development
and disease. The canonical Wnt/β-catenin pathway requires a single-span transmembrane …

Abstract Signalling by secreted Hedgehog (Hh) proteins is important for the development of
many tissues and organs. Damage to components of the Hh signal-transduction pathway …

Hedgehogs (Hhs) are key signaling regulators of stem cell maintenance and tissue
patterning in embryos, and activating mutations in the pathway that increase Gli …

The hedgehog pathway, initially discovered by two Nobel laureates Drs E Wieschaus and C
Nusslein-Volhard in Drosophila, is a major regulator for cell differentiation, tissue polarity …

Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily
conserved, recent studies indicate that fundamental differences exist between Drosophila …

The receptor class Frizzled, which has recently been categorized as a separate group of G
protein-coupled receptors by the International Union of Basic and Clinical Pharmacology …

Hedgehog (Hh) signaling regulates embryonic development and adult tissue homeostasis
through the GPCR-like protein Smoothened (Smo), but how vertebrate Smo is activated …