Phase transitions of associative biomacromolecules
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …
biomacromolecules, provide the driving forces for the formation and compositional …
Kinase regulation by liquid–liquid phase separation
TP López-Palacios, JL Andersen - Trends in Cell Biology, 2023 - cell.com
Liquid–liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal
regulation that could answer long-standing questions about how order is achieved in …
regulation that could answer long-standing questions about how order is achieved in …
Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units
SKK Galagedera, TP Dao, SE Enos… - Proceedings of the …, 2023 - National Acad Sciences
Biomolecular condensates form via multivalent interactions among key macromolecules and
are regulated through ligand binding and/or posttranslational modifications. One such …
are regulated through ligand binding and/or posttranslational modifications. One such …
Developments in describing equilibrium phase transitions of multivalent associative macromolecules
Biomolecular condensates are distinct cellular bodies that form and dissolve reversibly to
organize cellular matter and biochemical reactions in space and time. Condensates are …
organize cellular matter and biochemical reactions in space and time. Condensates are …
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level
Protein-protein and protein-RNA interactions are essential for cell function and survival.
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …
PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly
MC Chou, YH Wang, FY Chen, CY Kung, KP Wu… - Molecular Cell, 2023 - cell.com
Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency
through compartmentalizing DNPS enzymes during stressed conditions. However, the …
through compartmentalizing DNPS enzymes during stressed conditions. However, the …
Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
P McGoldrick, A Lau, Z You, TM Durcan, J Robertson - Cell Reports, 2023 - cell.com
A hexanucleotide (GGGGCC) n repeat expansion in C9orf72 causes amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD), eliciting toxic effects through generation …
sclerosis (ALS) and frontotemporal dementia (FTD), eliciting toxic effects through generation …
Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling
V Vamadevan, N Chaudhary… - Journal of Cell …, 2022 - journals.biologists.com
ABSTRACT Dishvelled-2 (Dvl2) is an essential component of Wnt pathway, which controls
several cell fate decisions during development, such as proliferation, survival and …
several cell fate decisions during development, such as proliferation, survival and …
E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure
Summary The E3 ligase E6AP/UBE3A has a dedicated binding site in the 26S proteasome
provided by the RAZUL domain of substrate receptor hRpn10/S5a/PSMD4. Guided by …
provided by the RAZUL domain of substrate receptor hRpn10/S5a/PSMD4. Guided by …
Uncovering the molecular mechanism for dual effect of ATP on phase separation in FUS solution
Recent studies reported that adenosine triphosphate (ATP) could inhibit and enhance the
phase separation in prion-like proteins. The molecular mechanism underlying such a …
phase separation in prion-like proteins. The molecular mechanism underlying such a …