[HTML][HTML] Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment

X Xu, C Liu, Y Wang, O Koivisto, J Zhou, Y Shu… - Advanced drug delivery …, 2021 - Elsevier
Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …

Epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma: challenges and opportunities

Z Ling, B Cheng, X Tao - International journal of cancer, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90%
of all forms of oral cancer worldwide. Although great efforts have been made in the past …

Structural insight and development of EGFR tyrosine kinase inhibitors

T Amelia, RE Kartasasmita, T Ohwada, DH Tjahjono - Molecules, 2022 - mdpi.com
Lung cancer has a high prevalence, with a growing number of new cases and mortality
every year. Furthermore, the survival rate of patients with non-small-cell lung carcinoma …

Molecular targeting of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)

NEM Kaufman, S Dhingra, SD Jois, MGH Vicente - Molecules, 2021 - mdpi.com
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor
(VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins …

The universe of galectin-binding partners and their functions in health and disease

MF Troncoso, MT Elola, AG Blidner, L Sarrias… - Journal of Biological …, 2023 - ASBMB
Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

D Das, L Xie, J Hong - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
Lung cancer is a leading cause of cancer-related deaths worldwide. Non-small cell lung
cancer (NSCLC) accounts for the major portion (80–85%) of all lung cancer cases …

Implicative role of epidermal growth factor receptor and its associated signaling partners in the pathogenesis of Alzheimer's disease

PK Jayaswamy, M Vijaykrishnaraj, P Patil… - Ageing Research …, 2023 - Elsevier
Epidermal growth factor receptor (EGFR) plays a pivotal role in early brain development,
although its expression pattern declines in accordance with the maturation of the active …

Natural tyrosine kinase inhibitors acting on the epidermal growth factor receptor: Their relevance for cancer therapy

Y Liang, T Zhang, J Zhang - Pharmacological Research, 2020 - Elsevier
Epidermal growth factor receptor (EGFR), also known as ErbB-1/HER-1, plays a key role in
the regulation of the cell proliferation, migration, differentiation, and survival. Since the …

Mechanisms of cancer inhibition by local anesthetics

Y Zhang, Y Jing, R Pan, K Ding, R Chen… - Frontiers in …, 2021 - frontiersin.org
The use of local anesthetics during surgical treatment of cancer patients is an important part
of perioperative analgesia. In recent years, it has been showed that local anesthetics can …

Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance

S Maity, KSR Pai, Y Nayak - Pharmacological Reports, 2020 - Springer
Background The epidermal growth factor receptor (EGFR) inhibitors represent the first-line
therapy regimen for non-small cell lung cancer (NSCLC). Most of these inhibitors target the …