Targeting HER2-positive breast cancer: advances and future directions
SM Swain, M Shastry, E Hamilton - Nature reviews Drug discovery, 2023 - nature.com
The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target
was a major breakthrough for the treatment of highly aggressive HER2-positive breast …
was a major breakthrough for the treatment of highly aggressive HER2-positive breast …
CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
Dendritic cell biology and its role in tumor immunotherapy
Y Wang, Y Xiang, VW Xin, XW Wang, XC Peng… - Journal of hematology & …, 2020 - Springer
As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy
A Basu, G Ramamoorthi, G Albert, C Gallen… - Frontiers in …, 2021 - frontiersin.org
Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells
in the tumor which are critical for activation of anti-tumor response either directly by …
in the tumor which are critical for activation of anti-tumor response either directly by …
Engineering dendritic cell vaccines to improve cancer immunotherapy
CR Perez, M De Palma - Nature communications, 2019 - nature.com
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …
Breast cancer vaccines: disappointing or promising?
SY Zhu, KD Yu - Frontiers in Immunology, 2022 - frontiersin.org
Breast cancer has become the most commonly diagnosed cancer globally. The relapse and
metastasis of breast cancer remain a great challenge despite advances in chemotherapy …
metastasis of breast cancer remain a great challenge despite advances in chemotherapy …
Clinical development of immunotherapies for HER2+ breast cancer: a review of HER2-directed monoclonal antibodies and beyond
RLB Costa, BJ Czerniecki - NPJ Breast Cancer, 2020 - nature.com
Human epidermal growth factor receptor 2–positive (HER2+) breast cancer accounts for~
25% of breast cancer cases. Monoclonal antibodies (mAbs) against HER2 have led to …
25% of breast cancer cases. Monoclonal antibodies (mAbs) against HER2 have led to …
Vaccine therapies for cancer: then and now
MA Morse, WR Gwin III, DA Mitchell - Targeted oncology, 2021 - Springer
There are strong biologic and preclinical rationales for the development of therapeutic
cancer vaccines; however, the clinical translation of this treatment strategy has been …
cancer vaccines; however, the clinical translation of this treatment strategy has been …
Recent advances in exosome-based immunotherapy applied to cancer
Cancer stands as a prominent contributor to global mortality rates, necessitating immediate
attention toward the exploration of its treatment options. Extracellular vesicles have been …
attention toward the exploration of its treatment options. Extracellular vesicles have been …