Derivatizing agents for spectrophotometric and spectrofluorimetric determination of pharmaceuticals: a review

V Kumar Vashistha, R Bala… - Journal of Taibah …, 2023 - Taylor & Francis
Most drug structures lack appropriate chromophores that can be examined at wavelengths
other than the generic UV part of the electromagnetic spectrum. Indirect spectrophotometric …

Nano-scale multi-spectroscopic analysis of the anti-fibromyalgia drug pregabalin based on dihydropyridine ring formation with sustainability and whiteness evaluation

MA El Hamd, RH Obaydo, MI Helmy, WA Mahdi… - … Acta Part A: Molecular …, 2025 - Elsevier
This research addresses the challenge of analyzing pregabalin, a primary amine in a
zwitterionic structure, which is difficult to evaluate due to its lack of chromatophore. The study …

Chemometrically Assisted Optimization of Pregabalin Fluorescent Derivatization Reaction with a Novel Xanthone Analogue and Validation of the Method for the …

N Kritikos, A Iliou, AD Kalampaliki, E Gikas, IK Kostakis… - Molecules, 2022 - mdpi.com
Quantitation of chromophore-free analytes is always a challenge. To this purpose,
derivatization of the analyte constitutes a common strategy, leading to a product with a …