Mechanistic insights into the pharmacological significance of silymarin
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …
Natural products from plants targeting key enzymes for the future development of antidiabetic agents
R Mata, L Flores-Bocanegra… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2000 to January 2023 Diabetes is a metabolic disease of serious concern
nowadays, with a negative economic impact. In 2021, the International Diabetes Federation …
nowadays, with a negative economic impact. In 2021, the International Diabetes Federation …
A comprehensive review on glucokinase activators: promising agents for the treatment of type 2 diabetes
R Thilagavathi, MS Hosseini‐Zare… - Chemical Biology & …, 2022 - Wiley Online Library
Glucokinase is a key enzyme which converts glucose into glucose‐6‐phosphate in the liver
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …
A systematic analysis of anti-diabetic medicinal plants from cells to clinical trials
Background Diabetes is one of the fastest-growing health emergencies of the 21 st century,
placing a severe economic burden on many countries. Current management approaches …
placing a severe economic burden on many countries. Current management approaches …
Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases
Plants and their derived phytochemicals have a long history of treating a wide range of
illnesses for several decades. They are believed to be the origin of a diverse array of …
illnesses for several decades. They are believed to be the origin of a diverse array of …
Natural hypoglycaemic bioactives: Newer avenues and newer possibilities
The incidences of endocrine and metabolic disorders like diabetes have increased
worldwide. Several proposed molecular pathways mechanisms for the management of …
worldwide. Several proposed molecular pathways mechanisms for the management of …
Clinical investigation of glucokinase activators for the restoration of glucose homeostasis in diabetes
P Li, D Zhu - Journal of Diabetes, 2024 - Wiley Online Library
As a sensor, glucokinase (GK) controls glucose homeostasis, which progressively declines
in patients with diabetes. GK maintains the equilibrium of glucose levels and regulates the …
in patients with diabetes. GK maintains the equilibrium of glucose levels and regulates the …
Effects of a Novel Glucokinase Activator, Dorzagliatin, on Glycemic Control and Glucose Fluctuation in Drug‐Naïve Patients with Type 2 Diabetes Mellitus
Y Wang, X Su, W Zhang, Y Zhou, X Zhou… - International Journal …, 2023 - Wiley Online Library
Aim. The prevalence rate of type 2 diabetes mellitus (T2DM) has been increasing and a
large proportion of patients still do not achieve adequate or sustainable glycemic control on …
large proportion of patients still do not achieve adequate or sustainable glycemic control on …
In-silico and in-vitro hybrid approach to identify glucagon-like peptide-1 receptor agonists from anti-diabetic natural products
D Chatterjee, N Vhora, A Goswami, A Hiray… - Natural Product …, 2023 - Taylor & Francis
Natural products have contributed immensely towards the treatment of various diseases
including diabetes. Here, a database of small molecules from nature possessing antidiabetic …
including diabetes. Here, a database of small molecules from nature possessing antidiabetic …
Role of bioactive phytoconstituents as modulators of hepatic carbohydrates metabolising enzymes: a target specific approach to treat diabetes mellitus
S Sharma, M Choudhary… - Current Diabetes …, 2022 - ingentaconnect.com
Diabetes mellitus is the most prevalent malady, becoming a leading public health concern
around the world. It is a chronic endocrine metabolic disturbance that is accompanied by the …
around the world. It is a chronic endocrine metabolic disturbance that is accompanied by the …