Mechanistic insights into the pharmacological significance of silymarin

K Wadhwa, R Pahwa, M Kumar, S Kumar, PC Sharma… - Molecules, 2022 - mdpi.com
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …

Natural products from plants targeting key enzymes for the future development of antidiabetic agents

R Mata, L Flores-Bocanegra… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2000 to January 2023 Diabetes is a metabolic disease of serious concern
nowadays, with a negative economic impact. In 2021, the International Diabetes Federation …

A comprehensive review on glucokinase activators: promising agents for the treatment of type 2 diabetes

R Thilagavathi, MS Hosseini‐Zare… - Chemical Biology & …, 2022 - Wiley Online Library
Glucokinase is a key enzyme which converts glucose into glucose‐6‐phosphate in the liver
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …

A systematic analysis of anti-diabetic medicinal plants from cells to clinical trials

S Omale, KI Amagon, TO Johnson, SK Bremner… - PeerJ, 2023 - peerj.com
Background Diabetes is one of the fastest-growing health emergencies of the 21 st century,
placing a severe economic burden on many countries. Current management approaches …

Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases

P Chauhan, K Wadhwa, R Mishra, S Gupta… - Molecular …, 2024 - Springer
Plants and their derived phytochemicals have a long history of treating a wide range of
illnesses for several decades. They are believed to be the origin of a diverse array of …

Natural hypoglycaemic bioactives: Newer avenues and newer possibilities

RK Paul, K Raza - Phytotherapy Research, 2024 - Wiley Online Library
The incidences of endocrine and metabolic disorders like diabetes have increased
worldwide. Several proposed molecular pathways mechanisms for the management of …

Clinical investigation of glucokinase activators for the restoration of glucose homeostasis in diabetes

P Li, D Zhu - Journal of Diabetes, 2024 - Wiley Online Library
As a sensor, glucokinase (GK) controls glucose homeostasis, which progressively declines
in patients with diabetes. GK maintains the equilibrium of glucose levels and regulates the …

Effects of a Novel Glucokinase Activator, Dorzagliatin, on Glycemic Control and Glucose Fluctuation in Drug‐Naïve Patients with Type 2 Diabetes Mellitus

Y Wang, X Su, W Zhang, Y Zhou, X Zhou… - International Journal …, 2023 - Wiley Online Library
Aim. The prevalence rate of type 2 diabetes mellitus (T2DM) has been increasing and a
large proportion of patients still do not achieve adequate or sustainable glycemic control on …

In-silico and in-vitro hybrid approach to identify glucagon-like peptide-1 receptor agonists from anti-diabetic natural products

D Chatterjee, N Vhora, A Goswami, A Hiray… - Natural Product …, 2023 - Taylor & Francis
Natural products have contributed immensely towards the treatment of various diseases
including diabetes. Here, a database of small molecules from nature possessing antidiabetic …

Role of bioactive phytoconstituents as modulators of hepatic carbohydrates metabolising enzymes: a target specific approach to treat diabetes mellitus

S Sharma, M Choudhary… - Current Diabetes …, 2022 - ingentaconnect.com
Diabetes mellitus is the most prevalent malady, becoming a leading public health concern
around the world. It is a chronic endocrine metabolic disturbance that is accompanied by the …