Human aneuploidy: mechanisms and new insights into an age-old problem
SI Nagaoka, TJ Hassold, PA Hunt - Nature Reviews Genetics, 2012 - nature.com
Trisomic and monosomic (aneuploid) embryos account for at least 10% of human
pregnancies and, for women nearing the end of their reproductive lifespan, the incidence …
pregnancies and, for women nearing the end of their reproductive lifespan, the incidence …
[HTML][HTML] Long noncoding RNAs and repetitive elements: junk or intimate evolutionary partners?
Our recent ability to sequence entire genomes, along with all of their transcribed RNAs, has
led to the surprising finding that only∼ 1% of the human genome is used to encode proteins …
led to the surprising finding that only∼ 1% of the human genome is used to encode proteins …
[HTML][HTML] Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …
series of developmental transitions that are poorly characterised at the molecular level …
[HTML][HTML] Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 …
Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are
repaired by recombination from homologous chromosomes (homologues). In a wide variety …
repaired by recombination from homologous chromosomes (homologues). In a wide variety …
[HTML][HTML] Reprogramming of meiotic chromatin architecture during spermatogenesis
Chromatin organization undergoes drastic reconfiguration during gametogenesis. However,
the molecular reprogramming of three-dimensional chromatin structure in this process …
the molecular reprogramming of three-dimensional chromatin structure in this process …
The consequences of asynapsis for mammalian meiosis
PS Burgoyne, SK Mahadevaiah… - Nature Reviews Genetics, 2009 - nature.com
During mammalian meiosis, synapsis of paternal and maternal chromosomes and the
generation of DNA breaks are needed to allow reshuffling of parental genes. In mammals …
generation of DNA breaks are needed to allow reshuffling of parental genes. In mammals …
Meiotic silencing in mammals
JMA Turner - Annual review of genetics, 2015 - annualreviews.org
Meiosis is essential for reproduction in sexually reproducing organisms. A key stage in
meiosis is the synapsis of maternal and paternal homologous chromosomes, accompanied …
meiosis is the synapsis of maternal and paternal homologous chromosomes, accompanied …
The meiotic checkpoint network: step-by-step through meiotic prophase
VV Subramanian… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
The generation of haploid gametes by meiosis is a highly conserved process for sexually
reproducing organisms that, in almost all cases, involves the extensive breakage of …
reproducing organisms that, in almost all cases, involves the extensive breakage of …
[HTML][HTML] A role for retrotransposon LINE-1 in fetal oocyte attrition in mice
Fetal oocyte attrition (FOA) is a conserved but poorly understood process of elimination of
more than two-thirds of meiotic prophase I (MPI) oocytes before birth. We now implicate …
more than two-thirds of meiotic prophase I (MPI) oocytes before birth. We now implicate …
[HTML][HTML] Molecular control of rodent spermatogenesis
Spermatogenesis is a complex developmental process that ultimately generates mature
spermatozoa. This process involves a phase of proliferative expansion, meiosis, and …
spermatozoa. This process involves a phase of proliferative expansion, meiosis, and …