Objective To investigate the prevalence and spectrum of BRCA1 and BRCA2 mutations in
Chinese Hakka patients with breast and ovarian cancer. Methods A total of 1,664 breast or …

Genetic variation is a well-known contributor to the onset and progression of cancer. The
goal of this study is to provide a comprehensive examination of the nucleotide and …

Breast cancer is clinically and biologically heterogeneous and is classified into different
subtypes according to the molecular landscape of the tumor. Triple-negative breast cancer is …

Gene mutations are a source of genetic instability which fuels the progression of cancer.
Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of …

Heart failure (HF) and cancer are the two leading causes of death worldwide and affect one
another in a bidirectional way. We aimed to identify hub therapeutic genes as potential …

Introduction Breast cancer is the most common malignant tumor in women, seriously
threatening health and survival. TP-dependent DNA helicase Q1 (RECQL) is a breast …

三阴性乳腺癌(TNBC) 是一类治疗困难, 预后较差, 术后早期易复发且易转移的乳腺癌.
发病呈低龄化趋势, 种族差异大, 具有明显的遗传易感性, 因此迫切需要阐明TNBC …

Various research pieces of evidence have been published in recent years, establishing the
increasing prevalence of early colon cancer among young people. In this background, the …

Background/Objectives: The presence of BRCA1/2 gene mutation significantly impacts the
current and future management of patients. Germline BRCA1/2 mutations are associated …

Introduction It is known that BRCA1 and BRCA2 genes' mutation carriers are predisposed to
breast and ovarian cancers and other organ cancers such as prostate, colon and cervix. In …