Epicardial adipose tissue in contemporary cardiology

G Iacobellis - Nature reviews cardiology, 2022 - nature.com
Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area
appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and …

Epidemiology and modifiable risk factors for atrial fibrillation

AD Elliott, ME Middeldorp, IC Van Gelder… - Nature Reviews …, 2023 - nature.com
The global prevalence of atrial fibrillation (AF) has increased substantially over the past
three decades and is currently approximately 60 million cases. Incident AF and its clinical …

Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology

D Dobrev, J Heijman, R Hiram, N Li… - Nature Reviews …, 2023 - nature.com
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review

AC Ernault, VMF Meijborg, R Coronel - Journal of the American College of …, 2021 - jacc.org
Obesity is a significant risk factor for arrhythmic cardiovascular death. Interactions between
epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the …

Management of atrial fibrillation across the spectrum of heart failure with preserved and reduced ejection fraction

YNV Reddy, BA Borlaug, BJ Gersh - Circulation, 2022 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia among patients with heart failure (HF),
and HF is the most common cause of death for patients presenting with clinical AF. AF is …

Epicardial adipose tissue and outcome in heart failure with mid-range and preserved ejection fraction

G van Woerden, DJ van Veldhuisen… - Circulation: Heart …, 2022 - Am Heart Assoc
Background: Epicardial adipose tissue (EAT) accumulation is thought to play a role in the
pathophysiology of heart failure (HF) with mid-range and preserved ejection fraction, but its …

Obesity and atrial fibrillation: a narrative review from arrhythmogenic mechanisms to clinical significance

H Shu, J Cheng, N Li, Z Zhang, J Nie, Y Peng… - Cardiovascular …, 2023 - Springer
The prevalence of obesity and atrial fibrillation (AF), which are inextricably linked, is rapidly
increasing worldwide. Obesity rates are higher among patients with AF than healthy …

Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Semaglutide modulates prothrombotic and atherosclerotic mechanisms, associated with epicardial fat, neutrophils and endothelial cells network

D García-Vega, D Sánchez-López… - Cardiovascular …, 2024 - Springer
Background Obesity has increased in recent years with consequences on diabetes and
other comorbidities. Thus, 1 out of 3 diabetic patients suffers cardiovascular disease (CVD) …

Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell

T Gong, X Zhang, Z Peng, Y Ye, R Liu, Y Yang… - Communications …, 2022 - nature.com
Sepsis-induced acute lung injury (ALI) is a serious sepsis complication and the prevailing
cause of death. Circulating plasma exosomes might exert a key role in regulating …