HTLV-1 infection and pathogenesis: New insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis

A Dykie, T Wijesinghe, AB Rabson, K Madugula… - Pathogens, 2020 - mdpi.com
Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated
with various clinical syndromes including co-infection with Strongyloides stercoralis, which is …

Precise excision of HTLV-1 provirus with a designer-recombinase

T Rojo-Romanos, J Karpinski, S Millen, N Beschorner… - Molecular Therapy, 2023 - cell.com
The human T cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that persists as a
provirus in the genome of infected cells and can lead to adult T cell leukemia (ATL) …

Milk transmission of mammalian retroviruses

LM Kemeter, A Birzer, S Heym, AK Thoma-Kress - Microorganisms, 2023 - mdpi.com
The transmission of viruses from one host to another typically occurs through horizontal or
vertical pathways. The horizontal pathways include transmission amongst individuals …

Mouse Models for HTLV-1 Infection and Adult T Cell Leukemia

S Nakajima, K Okuma - International Journal of Molecular Sciences, 2023 - mdpi.com
Adult T cell leukemia (ATL) is an aggressive hematologic disease caused by human T cell
leukemia virus type 1 (HTLV-1) infection. Various animal models of HTLV-1 infection/ATL …

[HTML][HTML] Tuning Rex rules HTLV-1 pathogenesis

K Nakano, T Watanabe - Frontiers in Immunology, 2022 - frontiersin.org
HTLV-1 is an oncovirus causing ATL and other inflammatory diseases such as HAM/TSP
and HU in about 5% of infected individuals. It is also known that HTLV-1-infected cells …

[HTML][HTML] Antisense transcripts and antisense protein: a new perspective on human immunodeficiency virus type 1

J Savoret, JM Mesnard, A Gross, N Chazal - Frontiers in Microbiology, 2021 - frontiersin.org
It was first predicted in 1988 that there may be an Open Reading Frame (ORF) on the
negative strand of the Human Immunodeficiency Virus type 1 (HIV-1) genome that could …

STLV-1 Commonly targets neurons in the brain of asymptomatic non-human primates

B Rocamonde, S Alais, R Pelissier, V Moulin… - Mbio, 2023 - Am Soc Microbiol
The human T-cell leukemia virus (HTLV)-1 is responsible for an aggressive
neurodegenerative disease (HAM/TSP) and multiple neurological alterations. The capacity …

Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL …

A Hasegawa, M Murata, T Fujikawa, K Katagiri… - PLoS …, 2023 - journals.plos.org
A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals
develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative …

On race, human variation, and who gets and dies of sepsis

JF Brinkworth, JG Shaw - American Journal of Biological …, 2022 - Wiley Online Library
COVID‐19 has highlighted a brutal reality known for decades, that Black, Indigenous, and
People of Color bear a disproportionate burden of US annual sepsis cases. While plentiful …