Multiple forms of cell death: A focus on the PI3K/AKT pathway

J Xu, Y Li, M Kang, C Chang, H Wei… - Journal of Cellular …, 2023 - Wiley Online Library
Cell death is a natural biological process that occurs in living organisms. Since 1963,
extensive research has shed light on the occurrence, progress, and final outcome of cell …

[PDF][PDF] Yeast osmoregulation–glycerol still in pole position

A Blomberg - FEMS Yeast Research, 2022 - academic.oup.com
In response to osmotic dehydration cells sense, signal, alter gene expression, and
metabolically counterbalance osmotic differences. The main compatible solute/osmolyte that …

Phosphoproteomic Approaches for Identifying Phosphatase and Kinase Substrates

AG DeMarco, MC Hall - Molecules, 2023 - mdpi.com
Protein phosphorylation is a ubiquitous post-translational modification controlled by the
opposing activities of protein kinases and phosphatases, which regulate diverse biological …

Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes

S Fischer, J Bürgi, S Gabay-Maskit, R Maier… - Biological …, 2023 - degruyter.com
Peroxisomes are organelles with vital functions in metabolism and their dysfunction is
associated with human diseases. To fulfill their multiple roles, peroxisomes import nuclear …

[HTML][HTML] C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential …

RL Arribas, L Viejo, I Bravo, M Martínez… - European Journal of …, 2023 - Elsevier
Abstract Protein phosphatase 2A (PP2A) is an important Ser/Thr phosphatase that
participates in the regulation of multiple cellular processes. This implies that any deficient …

Short-term hypoxia in cells induces expression of genes which are enhanced in stressed cells

I Peciuliene, E Jakubauskiene, L Vilys, R Zinkeviciute… - Genes, 2022 - mdpi.com
All living organisms must respond to, and defend against, environmental stresses.
Depending on the extent and severity of stress, cells try to alter their metabolism and adapt …

Inducible degradation-coupled phosphoproteomics identifies PP2ARts1 as a novel eisosome regulator

AG DeMarco, MG Dibble, MC Hall - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction Reversible protein phosphorylation is an abundant post-translational
modification dynamically regulated by opposing kinases and phosphatases. Protein …

[HTML][HTML] PP2ARts1 antagonizes Rck2-mediated hyperosmotic stress signaling in yeast

DM Hollenstein, J Veis, N Romanov, G Gérecová… - Microbiological …, 2022 - Elsevier
In Saccharomyces cerevisiae, impairment of protein phosphatase PP2A Rts1 leads to
temperature and hyperosmotic stress sensitivity, yet the underlying mechanism and the …

Phosphoproteomic strategies for protein functional characterization of phosphatases and kinases

AG DeMarco - 2024 - hammer.purdue.edu
Protein phosphorylation is a ubiquitous post-translational modification controlled by the
opposing activities of protein kinases and phosphatases, which regulate diverse biological …