Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Adolescent idiopathic scoliosis is one of the most common spinal deformities, yet its cause is
unknown. Various theories look to biomechanical, neuromuscular, genetic, and …

Idiopathic scoliosis (IS) affects 3% of children worldwide, yet the mechanisms underlying this
spinal deformity remain unknown. Here we show that ptk7 mutant zebrafish, a faithful …

Abstract Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play
important roles in cancer stemness, respectively. However, little is known about interaction …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Adolescent idiopathic scoliosis (AIS), defined by an age at presentation of 11 to 18 years,
has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic …

Anthropogenic releases of plastics, persistent organic pollutants (POPs), and heavy metals
can impact the environment, including aquatic ecosystems. Nanoplastics (NPs) have …

Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a
strong female bias. By performing a genome-wide association study (GWAS) of 3,102 …

Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most
severe and common malformations of the central nervous system affecting 0.7–3 per 1000 …

Scoliosis is defined as the three-dimensional (3D) structural deformity of the spine with a
radiological lateral Cobb angle (a measure of spinal curvature) of≥ 10° that can be caused …