Modeling the impact of microgravity at the cellular level: implications for human disease

P Bradbury, H Wu, JU Choi, AE Rowan… - Frontiers in cell and …, 2020 - frontiersin.org
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

3D biofabrication and space: A 'far-fetched dream'or a 'forthcoming reality'?

N Majumder, S Ghosh - Biotechnology Advances, 2023 - Elsevier
The long duration space missions across the Low Earth Orbit (LEO) often expose the
voyagers to an abrupt zero gravity influence. The severe extraterrestrial cosmic radiation …

Some history and use of the random positioning machine, RPM, in gravity related research

JJWA Van Loon - Advances in Space research, 2007 - Elsevier
The first experiments using machines and instruments to manipulate gravity and thus learn
about its impact to this force onto living systems were performed by Sir Thomas Andrew …

World's first long-term colorectal cancer model by 3D bioprinting as a mechanism for screening oncolytic viruses

C McGuckin, N Forraz, C Milet, M Lacroix, Y Sbirkov… - Cancers, 2023 - mdpi.com
Simple Summary Although many new cancer drugs look like they are working in the
laboratory, they fail when tested on real people. This is often because the cancer cell models …

Gravity, a regulation factor in the differentiation of rat bone marrow mesenchymal stem cells

Y Huang, ZQ Dai, SK Ling, HY Zhang, YM Wan… - Journal of biomedical …, 2009 - Springer
Background Stem cell therapy has emerged as a potential therapeutic option for tissue
engineering and regenerative medicine, but many issues remain to be resolved, such as the …

Simulated microgravity with floating environment promotes migration of non-small cell lung cancers

CB Ahn, JH Lee, DG Han, HW Kang, SH Lee, JI Lee… - Scientific reports, 2019 - nature.com
A migration of cancer is one of the most important factors affecting cancer therapy.
Particularly, a cancer migration study in a microgravity environment has gained attention as …

Scaffold-based bone tissue engineering in microgravity: potential, concerns and implications

F Mochi, E Scatena, D Rodriguez, MP Ginebra… - NPJ …, 2022 - nature.com
One of humanity's greatest challenges is space exploration, which requires an in-depth
analysis of the data continuously collected as a necessary input to fill technological gaps …

Detrimental effects of microgravity on mouse preimplantation development in vitro

S Wakayama, Y Kawahara, C Li, K Yamagata, L Yuge… - PloS one, 2009 - journals.plos.org
Sustaining life beyond Earth either on space stations or on other planets will require a clear
understanding of how the space environment affects key phases of mammalian …

Customized small-sized clinostat using 3D printing and gas-permeable polydimethylsiloxane culture dish

D Kim, QTT Nguyen, S Lee, KM Choi, EJ Lee, JY Park - npj Microgravity, 2023 - nature.com
Over the past few decades, research on life in space has increased. Owing to the expensive
nature of and the challenges associated with conducting experiments in real space …

Simulated microgravity effects on nonsmall cell lung cancer cell proliferation and migration

JH Chung, CB Ahn, KH Son, E Yi… - … medicine and human …, 2017 - ingentaconnect.com
BACKGROUND: Despite improvements in medical technology, lung cancer metastasis
remains a global health problem. The effects of microgravity on cell morphology, structure …