Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

The mRNA coding sequence defines not only the amino acid sequence of the protein, but
also the speed at which the ribosome move along the mRNA while making the protein. The …

In light of the numerous studies identifying post-transcriptional regulators on the surface of
the endoplasmic reticulum (ER), we asked whether there are factors that regulate …

The speed of protein synthesis can dramatically change when consecutively charged
residues are incorporated into an elongating nascent protein by the ribosome. The …

The transcriptional control of sporulation in Bacillus subtilis is reasonably well understood,
but its translational control is underexplored. Here, we use RNA-seq, ribosome profiling and …

The strategies adopted by viruses to reprogram the translation and protein quality control
machinery and promote infection are poorly understood. Here, we report that the viral …

Stability of eukaryotic mRNAs is associated with their codon, amino acid, and GC content.
Yet, coding sequence motifs that predictably alter mRNA stability in human cells remain …

Abstract Topoisomerase 3β (TOP3B) and TDRD3 form a dual-activity topoisomerase
complex that interacts with FMRP and can change the topology of both DNA and RNA. Here …

Introduction: Translation is a crucial stage of gene expression. It may also act as an
additional layer of regulation that plays an important role in gene expression and function …

Translational regulation plays the most critical role in gene expression. Ribosome profiling
sequencing (Ribo-Seq) is one of the methods to study translation and its regulation. It is a …