PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

Polo-like kinases (Plks) are potent regulators of M phase that are conserved from yeasts to
humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly …

Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …

Summary Background The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1)
have been characterized extensively to further understanding of mitotic mechanisms and as …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. New
techniques, including the application of small-molecule inhibitors, have greatly expanded …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

Mitotic phosphorylation of the spindle checkpoint component BubR1 is highly conserved
throughout evolution. Here, we demonstrate that BubR1 is phosphorylated on the Cdk1 site …