Immunology of human fibrosis
M Bhattacharya, P Ramachandran - Nature Immunology, 2023 - nature.com
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
[HTML][HTML] Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis
J Åkesson, S Hojjati, S Hellberg, J Raffetseder… - Nature …, 2023 - nature.com
Sensitive and reliable protein biomarkers are needed to predict disease trajectory and
personalize treatment strategies for multiple sclerosis (MS). Here, we use the highly …
personalize treatment strategies for multiple sclerosis (MS). Here, we use the highly …
Meaningful Endpoints for Idiopathic Pulmonary Fibrosis (IPF) Clinical Trials: Emphasis on 'Feels, Functions, Survives'. Report of a Collaborative Discussion in a …
G Raghu, M Ghazipura, TR Fleming… - American journal of …, 2024 - atsjournals.org
Background: Idiopathic pulmonary fibrosis (IPF) carries significant mortality and
unpredictable progression, with limited therapeutic options. Designing trials with patient …
unpredictable progression, with limited therapeutic options. Designing trials with patient …
[HTML][HTML] De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated
cancer and fibrosis targets of considerable therapeutic importance. Compounds that can …
cancer and fibrosis targets of considerable therapeutic importance. Compounds that can …
Proteomic biomarkers of survival in idiopathic pulmonary fibrosis
Rationale: Idiopathic pulmonary fibrosis (IPF) causes progressive lung scarring and high
mortality. Reliable and accurate prognostic biomarkers are urgently needed. Objectives: To …
mortality. Reliable and accurate prognostic biomarkers are urgently needed. Objectives: To …
[HTML][HTML] Recent advances of artificial intelligence applications in interstitial lung diseases
KP Exarchos, G Gkrepi, K Kostikas, A Gogali - Diagnostics, 2023 - mdpi.com
Interstitial lung diseases (ILDs) comprise a rather heterogeneous group of diseases varying
in pathophysiology, presentation, epidemiology, diagnosis, treatment and prognosis. Even …
in pathophysiology, presentation, epidemiology, diagnosis, treatment and prognosis. Even …
CYFRA 21-1 predicts progression in idiopathic pulmonary fibrosis: a prospective longitudinal analysis of the PROFILE cohort
PL Molyneaux, WA Fahy, AJ Byrne… - American journal of …, 2022 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive and inevitably fatal condition
for which there are a lack of effective biomarkers to guide therapeutic decision making …
for which there are a lack of effective biomarkers to guide therapeutic decision making …
[HTML][HTML] Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Background Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of
extracellular matrix in the pulmonary interstitium and progressive functional decline. We …
extracellular matrix in the pulmonary interstitium and progressive functional decline. We …