Sequestration of cellular interacting partners by protein aggregates: implication in a loss‐of‐function pathology
H Yang, HY Hu - The FEBS journal, 2016 - Wiley Online Library
Protein misfolding and aggregation are a hallmark of several neurodegenerative diseases
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …
Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a CAG expansion in the gene-encoding Huntingtin (HTT). Transcriptome dysregulation is a …
a CAG expansion in the gene-encoding Huntingtin (HTT). Transcriptome dysregulation is a …
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src
Z Li, X Yang, R Fu, Z Wu, S Xu, J Jiao, M Qian… - Nature …, 2024 - nature.com
Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency in mice
leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src …
leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src …
Aggregation of polyglutamine-expanded ataxin 7 protein specifically sequesters ubiquitin-specific protease 22 and deteriorates its deubiquitinating function in the Spt …
H Yang, S Liu, WT He, J Zhao, LL Jiang… - Journal of Biological …, 2015 - ASBMB
Human ataxin 7 (Atx7) is a component of the deubiquitination module (DUBm) in the Spt-
Ada-Gcn5-acetyltransferase (SAGA) complex for transcriptional regulation, and expansion of …
Ada-Gcn5-acetyltransferase (SAGA) complex for transcriptional regulation, and expansion of …
Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation
JY Hong, DD Wang, W Xue, HW Yue, H Yang… - Scientific Reports, 2019 - nature.com
Abstract Ataxin-7 (Atx7) is a disease-related protein associated with the pathogenesis of
spinocerebellar ataxia 7, while its polyglutamine (polyQ) tract in N-terminus is the causative …
spinocerebellar ataxia 7, while its polyglutamine (polyQ) tract in N-terminus is the causative …
[PDF][PDF] Kiss1/Gpr54 Prevents Bone Loss through Src Dephosphorylation by Dusp18 in Osteoclasts
Z Li, X Yang, J Jiao, Z Wu, Z Wu, S Xu, W Li, G Ma… - 2021 - pdfs.semanticscholar.org
SUMMARY 1 Osteoclasts are over-activated as we age, which results in bone loss. Src-
deficient mice lead to 2 only one phenotype-severe osteopetrosis due to functional defect in …
deficient mice lead to 2 only one phenotype-severe osteopetrosis due to functional defect in …
Molecular mechanism (s) underlying neurodegeneration in SCA7 disease: Role of NOX enzymes and oxidative stress
A Ajayi - 2015 - diva-portal.org
Abstract Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative
disorder caused by a CAG trinucleotide expansion in the SCA7 gene, resulting in …
disorder caused by a CAG trinucleotide expansion in the SCA7 gene, resulting in …