How many cell types are in the kidney and what do they do?
The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …
Cellular and molecular mechanisms of kidney fibrosis
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …
injury or maladaptive repair. It is considered as the underlying pathological process of …
Synergistic insights into human health from aptamer-and antibody-based proteomic profiling
M Pietzner, E Wheeler, J Carrasco-Zanini… - Nature …, 2021 - nature.com
Affinity-based proteomics has enabled scalable quantification of thousands of protein targets
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …
Genomics of hypertension: the road to precision medicine
S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
Salt sensitivity of blood pressure: a scientific statement from the American Heart Association
F Elijovich, MH Weinberger, CAM Anderson… - …, 2016 - Am Heart Assoc
Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …
Autosomal dominant tubulointerstitial kidney disease
Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …
Impact of salt intake on the pathogenesis and treatment of hypertension
P Rust, C Ekmekcioglu - Hypertension: from basic research to clinical …, 2017 - Springer
Excessive dietary salt (sodium chloride) intake is associated with an increased risk for
hypertension, which in turn is especially a major risk factor for stroke and other …
hypertension, which in turn is especially a major risk factor for stroke and other …
Uromodulin: from physiology to rare and complex kidney disorders
O Devuyst, E Olinger, L Rampoldi - Nature Reviews Nephrology, 2017 - nature.com
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …
and is the most abundant protein in normal urine. The function of uromodulin remains …
Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste
products, affects 700 million people globally. Genome-wide association studies (GWASs) …
products, affects 700 million people globally. Genome-wide association studies (GWASs) …