Tendon explant models for physiologically relevant in vitro study of tissue biology – a perspective
SL Wunderli, U Blache, JG Snedeker - Connective tissue research, 2020 - Taylor & Francis
Background: Tendon disorders increasingly afflict our aging society but we lack the scientific
understanding to clinically address them. Clinically relevant models of tendon disease are …
understanding to clinically address them. Clinically relevant models of tendon disease are …
Tendon extracellular matrix assembly, maintenance and dysregulation throughout life
Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …
Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons
AJ De Micheli, JB Swanson… - … of Physiology-Cell …, 2020 - journals.physiology.org
Tendon is a dense connective tissue that stores and transmits forces between muscles and
bones. Cellular heterogeneity is increasingly recognized as an important factor in the …
bones. Cellular heterogeneity is increasingly recognized as an important factor in the …
[HTML][HTML] Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function
JE Ackerman, KT Best, SN Muscat, EM Pritchett… - Cell reports, 2022 - cell.com
Tendon injuries heal via a scar-mediated response, and there are no biological approaches
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …
The rat Achilles and patellar tendons have similar increases in mechanical properties but become transcriptionally divergent during postnatal development
D Steffen, A Avey, MJ Mienaltowski… - The Journal of …, 2023 - Wiley Online Library
The molecular events that drive post‐natal tendon development are poorly characterized. In
this study, we profiled morphological, mechanical, and transcriptional changes in the rat …
this study, we profiled morphological, mechanical, and transcriptional changes in the rat …
[HTML][HTML] Scleraxis is required for the growth of adult tendons in response to mechanical loading
JP Gumucio, MM Schonk, YA Kharaz, E Comerford… - JCI insight, 2020 - ncbi.nlm.nih.gov
Scleraxis is a basic helix-loop-helix transcription factor that plays a central role in promoting
tenocyte proliferation and matrix synthesis during embryonic tendon development. However …
tenocyte proliferation and matrix synthesis during embryonic tendon development. However …
[HTML][HTML] Innate and adaptive immune cells implicated in tendon healing and disease
G Crosio, AH Huang - European cells & materials, 2022 - ncbi.nlm.nih.gov
Tendons perform a critical function in the musculoskeletal system by integrating muscle with
skeleton and enabling force transmission. Damage or degeneration of these tissues leads to …
skeleton and enabling force transmission. Damage or degeneration of these tissues leads to …
[HTML][HTML] Tendon stem/progenitor cell subpopulations and their implications in tendon biology
Tendon harbors a cell population that possesses stem cell characteristics such as
clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon …
clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon …
Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets
Y Yoshimoto, Y Oishi - Pharmacology & Therapeutics, 2023 - Elsevier
Skeletal muscle contraction is essential for the movement of our musculoskeletal system.
Tendons and ligaments that connect the skeletal muscles to bones in the correct position at …
Tendons and ligaments that connect the skeletal muscles to bones in the correct position at …
Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies
SL Tsai, MT Nödl, JL Galloway - Developmental Dynamics, 2021 - Wiley Online Library
Tendons are specialized matrix‐rich connective tissues that transmit forces from muscle to
bone and are essential for movement. As tissues that frequently transfer large mechanical …
bone and are essential for movement. As tissues that frequently transfer large mechanical …