Alzheimer's disease (AD) is the most common neurodegenerative disease and the most
common cause of dementia. Among various pathophysiological aspects, microglia are …

The concept of the glial-vascular unit (GVU) was raised recently to emphasize the close
associations between brain cells and cerebral vessels, and their coordinated reactions to …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease, leads to
blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction …

Although myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has a specific and
distinctive profile of clinical features, the disease remains an enigma because causal …

Lumateperone is indicated for the treatment of schizophrenia in adults and for depressive
episodes associated with bipolar I or II disorder (bipolar depression) in adults, as …

Cerebral blood flow (CBF) is important for the maintenance of brain function and its
dysregulation has been implicated in Alzheimer's disease (AD). Microglia associations with …

Increased soluble endoglin (sENG) has been observed in human brain arteriovenous
malformations (bAVMs). In addition, the overexpression of sENG in concurrence with …

The sophisticated function of the central nervous system (CNS) is largely supported by
proper interactions between neural cells and blood vessels. Accumulating evidence has …

Microglial activation and subsequent pathological neuroinflammation contribute to diabetic
retinopathy (DR). However, the underlying mechanisms of microgliosis, and means to …

Background Neurovascular glial unit (NVGU) dysfunction has been reported to be an early
and critical event in the pathophysiology of Alzheimer's disease (AD) and vascular dementia …