Bone tissue engineering (BTE) is a promising approach for repairing and regenerating
damaged bone tissue, using stem cells and scaffold structures. Among various stem cell …

Critical morphological requirements for pulp regeneration are tissues replete with
vascularisation, neuron formation, and dentin deposition. Autophagy was recently shown to …

Background CDKL5 (cyclin-dependent kinase-like 5) is mutated in many severe
neurodevelopmental disorders, including atypical wRett syndrome. CDKL5 was shown to …

It is a big challenge for bone healing under osteoporotic pathological condition with
impaired angiogenesis, osteogenesis and remodeling. In the present study, the effect of Ca …

Recent studies have shown that co-culture systems play an important role in bone tissue
engineering. In this study, human dental pulp stem cells (hDPSCs) were co-cultured with …

Periapical periodontitis results from pulpal infection leading to pulpal necrosis and
resorption of periapical bone. The current treatment is root canal therapy, which attempts to …

Long noncoding RNAs (lncRNAs) have recently emerged as an important class of regulatory
molecules in diverse biological processes, although lncRNA involvement in the odontoblast …

Dental pulp and periapical diseases make patients suffer from acute pain and economic
loss. Although root canal therapies, as demonstrated through evidence-based medicine, can …

Objectives Insulin-like growth factor 1 (IGF-1) is a broad-spectrum growth-promoting factor
that plays a key role in natural tooth development. Human dental pulp stem cells (hDPSCs) …

Dental pulp stem cells (DPSCs), as one type of mesenchymal stem cells (MSCs), have the
capability of self-renewal and multipotency to differentiate into several cell lineages …