Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular
functions throughout all phases of the cell cycle. Altered tubulin isotype composition of …

Macroautophagy/autophagy is a key catabolic process, essential for maintaining cellular
homeostasis and survival through the removal and recycling of unwanted cellular material …

Neurodegenerative diseases affect millions of people worldwide, yet there are currently no
effective treatments. Because risk of neurodegenerative disease substantially increases with …

Autophagy represents a conserved self-digestion program, which allows regulated
degradation of cellular material. Autophagy is activated by cellular stress, serum starvation …

Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic
target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient …

Macroautophagy/autophagy is a conserved intracellular degradation pathway that has
recently emerged as an integral part of plant responses to virus infection. The known …

The trabecular meshwork (TM) is a key regulatory tissue of intraocular pressure (IOP) in the
anterior chamber of eye. Dysfunction of the TM causes resistance to outflow of aqueous …

Specific nuclear sub-compartments that are regions of fundamental processes such as gene
expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent …

Rationale: Cisplatin (CDDP) is a broad-spectrum anticancer drug but chemoresistance to
CDDP impedes its wide use for cancer therapy. Autophagy is an event occurring in the …

Background Macroautophagy (hereafter referred to as autophagy) is an evolutionarily
conserved intracellular mechanism for lysosomal degradation of damaged cellular …