[HTML][HTML] The impact of toxic metal bioaccumulation on colorectal cancer: Unravelling the unexplored connection

R Bonfiglio, R Sisto, S Casciardi, V Palumbo… - Science of the Total …, 2024 - Elsevier
Colorectal cancer is a major public health concern, with increasing incidence and mortality
rates worldwide. Environmental factors, including exposure to toxic metals, such as lead …

[HTML][HTML] Intestinal homeostasis disruption in mice chronically exposed to arsenite-contaminated drinking water

A Domene, H Orozco, P Rodríguez-Viso… - Chemico-biological …, 2023 - Elsevier
Chronic exposure to inorganic arsenic [As (III) and As (V)] affects about 200 million people,
and is linked to a greater incidence of certain types of cancer. Drinking water is the main …

Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMAV) in adult female CD-1 mice. V. Toxicokinetic studies following …

NC Twaddle, M Vanlandingham, FA Beland… - Food and Chemical …, 2019 - Elsevier
Arsenic species contaminate food and water, with typical dietary intake below 1 μg/kg bw/d.
Exposure to arsenic in heavily contaminated drinking water is associated with human …

[HTML][HTML] Constructing interactive networks of functional genes and metabolites to uncover the cellular events related to colorectal cancer cell migration induced by …

R Zhang, J Sun, L Tu, W Lu, Y Li, T Luan… - Environment International, 2023 - Elsevier
Tumor cell migration induced by arsenite (iAs III) is closely associated with cancer
progression. However, transcriptomic and metabolic traits of migrative human cells exposed …

[HTML][HTML] Targeting and imaging colorectal cancer by activatable cell-penetrating peptides

Z Zeng, J Chen, S Luo, J Dong, H Hu… - American Journal of …, 2020 - ncbi.nlm.nih.gov
While it has been a great challenge to determine the positive status of metastasis lesions,
intraoperative tumor imaging, which can show tumor localization and facilitate intraoperative …

[HTML][HTML] Ethanol extract of Vitellaria paradoxa (Gaertn, F) leaves protects against sodium arsenite-induced toxicity in male wistar rats

A Oyibo, MA Gbadegesin, OA Odunola - Toxicology Reports, 2021 - Elsevier
The inadvertent exposure to arsenic has been associated with diverse diseases such as
cancers. Vitellaria paradoxa is a medicinal plant with antidiabetic and antiproliferative …

Effects of selenium on the immunotoxicity of subacute arsenic poisoning in chickens

Z Ren, Q Wu, H Deng, Y Yu, W Tang, Y Deng… - … Trace Element Research, 2021 - Springer
This study aimed to determine the effects of selenium on the immune toxicity of subacute
arsenic poisoning in chickens. Two hundred 8-day-old broilers were randomly divided into 5 …

Inorganic arsenic exposure promotes malignant progression by HDAC6‐mediated down‐regulation of HTRA1

J Chen, C Lei, D Nie, H Ge, J Li, C Lei… - Journal of Applied …, 2023 - Wiley Online Library
Inorganic arsenic (iAs) has been a human health concern and is associated with intestinal
malignancies. However, the molecular mechanisms of the iAs‐induced oncogenic process …

Tocopherol enhances the antioxidant Defense System and histomorphometric parameters in the gastrointestinal tract of rats treated with Sodium Arsenite

OO Oladokun, TC Olaleye, NM Moses… - Nigerian Journal of …, 2022 - ojshostng.com
Arsenic compromises the gastrointestinal integrity and function via the body's anti-oxidative
system breakdown. Hence, this study aimed to investigate the effects of tocopherol on redox …

Arsenic through the gastrointestinal tract

A Domene, P Rodríguez-Viso, A Sánchez… - Handbook of Arsenic …, 2023 - Elsevier
Chronic exposure to inorganic arsenic (As) through the diet is considered to be a worldwide
health problem. Epidemiological and mechanistic studies have evidenced its toxicity in …