MAIT cell development and functions: the microbial connection
F Legoux, M Salou, O Lantz - Immunity, 2020 - cell.com
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset,
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
HEG McWilliam, JA Villadangos - Nature Reviews Immunology, 2024 - nature.com
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …
CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
Off-the-shelf allogeneic T cell therapies for cancer: opportunities and challenges using naturally occurring “universal” donor T cells
Chimeric antigen receptor (CAR) engineered T cell therapies individually prepared for each
patient with autologous T cells have recently changed clinical practice in the management of …
patient with autologous T cells have recently changed clinical practice in the management of …
TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules
Chaperones tapasin and transporter associated with antigen processing (TAP)-binding
protein related (TAPBPR) associate with the major histocompatibility complex (MHC)-related …
protein related (TAPBPR) associate with the major histocompatibility complex (MHC)-related …
Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis
SK Wyatt-Johnson, HN Kersey, JF Codocedo… - Journal of …, 2023 - Springer
Background Neuroinflammation is an important feature of Alzheimer's disease (AD).
Understanding which aspects of the immune system are important in AD may lead to new …
Understanding which aspects of the immune system are important in AD may lead to new …
Antigen recognition by MR1-reactive T cells; MAIT cells, metabolites, and remaining mysteries
AJ Corbett, W Awad, H Wang, Z Chen - Frontiers in immunology, 2020 - frontiersin.org
Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented
by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors …
by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors …
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite
antigens derived from microbial vitamin B2 synthesis to activate mucosal-associated …
antigens derived from microbial vitamin B2 synthesis to activate mucosal-associated …
Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1
The Major Histocompatibility Complex class I–related protein 1 (MR1) presents small
molecule metabolites, drugs, and drug-like molecules that are recognized by MR1-reactive T …
molecule metabolites, drugs, and drug-like molecules that are recognized by MR1-reactive T …
Emerging role for MAIT cells in control of antimicrobial resistance
Antimicrobial resistance is a serious threat to global public health as antibiotics are losing
effectiveness due to rapid development of resistance. The human immune system facilitates …
effectiveness due to rapid development of resistance. The human immune system facilitates …