Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements
which have a profound effect on the biology of the organism. This includes transfer of …

Clostridium difficile is a leading cause of antibiotic-associated diarrhea. The mechanisms
underlying C. difficile expansion after microbiota disturbance are just emerging. We …

Clostridioides difficile causes antibiotic-induced diarrhoea and pseudomembranous colitis
in humans and animals. Current conventional treatment relies solely on antibiotics, but C …

Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections
with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine …

The Gram-positive obligate anaerobe Clostridium difficile causes potentially fatal intestinal
diseases. How this organism regulates virulence gene expression is poorly understood. In …

We show in this study that toxin production in Clostridium difficile is altered in cells which
can no longer form flagellar filaments. The impact of inactivation of fliC, CD0240, fliF, fliG …

Clostridium difficile infections have become a major healthcare concern in the last decade
during which the emergence of new strains has underscored this bacterium's capacity to …

The Clostridium difficile toxins A and B are primarily responsible for symptoms of C. difficile
associated disease and are prime targets for vaccine development. We describe a plasmid …

The response to iron limitation of several bacteria is regulated by the ferric uptake regulator
(Fur). The Fur-regulated transcriptional, translational and metabolic networks of the Gram …

The Gram-positive, anaerobic, endospore-forming bacterium Clostridium acetobutylicum
has considerable biotechnological potential due to its ability to produce solvents as …