Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells
Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …
Characterizing cellular heterogeneity in chromatin state with scCUT&Tag-pro
Technologies that profile chromatin modifications at single-cell resolution offer enormous
promise for functional genomic characterization, but the sparsity of the measurements and …
promise for functional genomic characterization, but the sparsity of the measurements and …
ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ
RNA labeling in situ has enormous potential to visualize transcripts and quantify their levels
in single cells, but it remains challenging to produce high levels of signal while also …
in single cells, but it remains challenging to produce high levels of signal while also …
Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells
Background Cardiac differentiation of human-induced pluripotent stem (hiPS) cells
consistently produces a mixed population of cardiomyocytes and non-cardiac cell types …
consistently produces a mixed population of cardiomyocytes and non-cardiac cell types …
Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment
Even amongst genetically identical cancer cells, therapy resistance often only emerges from
a very small subset of those cells. Much effort has gone into uncovering the molecular …
a very small subset of those cells. Much effort has gone into uncovering the molecular …
Modeling diabetic endothelial dysfunction with patient‐specific induced pluripotent stem cells
R Gorashi, N Rivera‐Bolanos, C Dang… - Bioengineering & …, 2023 - Wiley Online Library
Diabetes is a known risk factor for various cardiovascular complications, mediated by
endothelial dysfunction. Despite the high prevalence of this metabolic disorder, there is a …
endothelial dysfunction. Despite the high prevalence of this metabolic disorder, there is a …
[HTML][HTML] Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells
Pluripotency can be induced in somatic cells by the expression of the four “Yamanaka”
factors OCT4, KLF4, SOX2, and MYC. However, even in homogeneous conditions, usually …
factors OCT4, KLF4, SOX2, and MYC. However, even in homogeneous conditions, usually …
Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
Pluripotency can be induced in somatic cells by the expression of OCT4, KLF4, SOX2, and
MYC. Usually only a rare subset of cells reprogram, and the molecular characteristics of this …
MYC. Usually only a rare subset of cells reprogram, and the molecular characteristics of this …
Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells
Background Cells and tissues have a remarkable ability to adapt to genetic perturbations via
a variety of molecular mechanisms. Nonsense-induced transcriptional compensation, a form …
a variety of molecular mechanisms. Nonsense-induced transcriptional compensation, a form …
[HTML][HTML] A novel classification method for NSCLC based on the background interaction network and the edge-perturbation matrix
Y Tian, C Zhang, W Ma, A Huang, M Tian… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
The biological functional network of tumor tissues is relatively stable for a period of time and
under different conditions, so the impact of tumor heterogeneity is effectively avoided. Based …
under different conditions, so the impact of tumor heterogeneity is effectively avoided. Based …