Psychostimulants, including amphetamines and methylphenidate, are first-line
pharmacotherapies for individuals with attention-deficit/hyperactivity disorder (ADHD). This …

Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

For several decades, addiction has come to be viewed as a disorder of the dopamine
neurotransmitter system; however, this view has not led to new treatments. In this Opinion …

Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

Importance Stimulant use disorder is common, affecting between 0.3% and 1.1% of the
population, and costs more than $85 billion per year globally. There are no licensed …

The hypothesis that dopamine is important for reward has been proposed in a number of
forms, each of which has been challenged. Normally, rewarding stimuli such as food, water …

Aims To examine the literature regarding clinical pharmacokinetics, direct effects and
adverse clinical outcomes associated with methamphetamine use. Methods Relevant …

Imaging studies have revealed neurochemical and functional changes in the brains of drug-
addicted subjects that provide new insights into the mechanisms underlying addiction …

The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of
dopaminergic transmission at the D2 receptor. We measured in vivo occupancy of striatal D2 …

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic
transmission is associated with this illness, but direct observation of abnormalities of …