Chronic kidney disease (CKD) is a long-term condition in which the kidneys do not work
correctly. It has a high prevalence and represents a serious hazard to human health and …

The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Angiotensin II (AngII), the major effector peptide of renin–angiotensin system (RAS), is now
recognized as a growth factor that regulates cell growth and fibrosis, besides being a …

The contraction of granulation tissue from skin wounds was first described in the 1960s.
Later it was discovered that during tissue repair, fibroblasts undergo a change in phenotype …

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Diabetes is characterized by high glucose concentrations that lead, via several mechanisms
(glucose autoxidation, stimulation of the polyol pathway, activation of the reduced form of …

Following chronic liver injury of any etiology, there is progressive fibrosis. To date, removing
the causative agent is the only effective therapy to stop or even reverse liver fibrosis …

Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Background
We evaluated the role of aldosterone as a mediator of renal inflammation and fibrosis in a rat …

Diabetic vascular complication is a leading cause of end-stage renal failure, acquired
blindness, a variety of neuropathies and accelerated atherosclerosis, which could account …

Many experimental data have suggested that the renin-angiotensin system participates in
immune and inflammatory responses. Angiotensin II is involved in several steps of the …