Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …

Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

Single-molecule spatial transcriptomics protocols based on in situ sequencing or
multiplexed RNA fluorescent hybridization can reveal detailed tissue organization. However …

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

The vagus nerve is an indispensable body-brain connection that controls vital aspects of
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …

The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum,
controls food transport, digestion, nutrient uptake, and hormone production. By single-cell …

Methods for profiling genes at the single-cell level have revolutionized our ability to study
several biological processes and systems including development, differentiation, response …