A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping
The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses
Y Ma, E Frutos-Beltrán, D Kang… - Chemical Society …, 2021 - pubs.rsc.org
During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …
drug discovery culminating with the introduction of therapies able to stop human …
Translation inhibition and stress granules in the antiviral immune response
C McCormick, DA Khaperskyy - Nature Reviews Immunology, 2017 - nature.com
Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …
rapidly reprioritize the translation machinery in response to varied environmental assaults …
Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
V Boldescu, MAM Behnam, N Vasilakis… - Nature Reviews Drug …, 2017 - nature.com
Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …
[HTML][HTML] Recent advances in antiviral drug development towards dengue virus
B Troost, JM Smit - Current opinion in virology, 2020 - Elsevier
Highlights•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …
The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
CS Ryan, M Schröder - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
[HTML][HTML] Functional RNA during Zika virus infection
Zika virus (ZIKV; family Flaviviridae; genus Flavivirus) is a pathogenic mosquito-borne RNA
virus that currently threatens human health in the Americas, large parts of Asia and …
virus that currently threatens human health in the Americas, large parts of Asia and …
The multifaceted roles of NLRP3-modulating proteins in virus infection
The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
Wanted DEAD/H or alive: helicases winding up in cancers
W Cai, Z Xiong Chen, G Rane… - JNCI: Journal of the …, 2017 - academic.oup.com
Cancer is one of the most studied areas of human biology over the past century. Despite
having attracted much attention, hype, and investments, the search to find a cure for cancer …
having attracted much attention, hype, and investments, the search to find a cure for cancer …