Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Highlights•Sixteen leading groups review evidence for the therapeutic effects of
agmatine.•Agmatine modulatory action at multiple molecular targets is highlighted.• …

Agmatine is an endogenous neuromodulator that, based on animal studies, has the
potential for new drug development. As an endogenous aminoguanidine compound (1 …

Anxiety and stress-related disorders, namely posttraumatic stress disorder (PTSD),
generalized anxiety disorder (GAD), obsessive–compulsive disorder (ODC), social and …

Depression has a multifactorial etiology that arises from environmental, psychological,
genetic, and biological factors. Environmental stress and genetic factors acting through …

This study investigated the effect of melatonin in the mouse tail suspension test (TST), and
the contribution of N-methyl-d-aspartate (NMDA) receptors and the l-arginine-nitric oxide …

Abstract Ethnopharmacological relevance Radix Polygalae (RP) has been traditionally used
for the treatment of various psychiatric disorders in East Asia. Aim of the study Depression is …

Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

This study investigated the involvement of NMDA receptors and the l-arginine-nitric oxide
(NO) pathway in the antidepressant-like effects of zinc in the forced swimming test (FST) …

Ascorbic acid is highly concentrated in the brain, being considered as a neuromodulator.
This study investigated the effect of ascorbic acid in the tail suspension test (TST) and in the …