The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations

C Aisenbrey, A Marquette, B Bechinger - Antimicrobial Peptides: Basics …, 2019 - Springer
Even 30 years after the discovery of magainins, biophysical and structural investigations on
how these peptides interact with membranes can still bear surprises and add new …

[HTML][HTML] Unwrapping the structural and functional features of antimicrobial peptides from wasp venoms

HM Duque, C Dos Santos, J Brango-Vanegas… - Pharmacological …, 2024 - Elsevier
The study of wasp venoms has captured attention due to the presence of a wide variety of
active compounds, revealing a diverse array of biological effects. Among these compounds …

[HTML][HTML] Effect of N-terminal acetylation on lytic activity and lipid-packing perturbation induced in model membranes by a mastoparan-like peptide

DS Alvares, N Wilke, JR Neto - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Abstract L1A (IDGLKAIWKKVADLLKNT-NH2) is a peptide that displays a selective
antibacterial activity to Gram-negative bacteria without being hemolytic. Its lytic activity in …

Antimicrobial peptides interact with peptidoglycan

OP Neelay, CA Peterson, ME Snavely… - Journal of Molecular …, 2017 - Elsevier
Traditional therapeutics are losing effectiveness as bacterial resistance increases, and
antimicrobial peptides (AMPs) can serve as an alternative source for antimicrobial agents …

Revealing the mode of action of Halictine antimicrobial peptides: a comprehensive study with model membranes

TM Domingues, KR Perez, KA Riske - Langmuir, 2020 - ACS Publications
Antimicrobial peptides are innate host defense molecules with the ability to kill pathogens.
They have been widely studied for their membrane lytic activity and their potential to …

Mastoparan peptide causes mitochondrial permeability transition not by interacting with specific membrane proteins but by interacting with the phospholipid phase

T Yamamoto, M Ito, K Kageyama, K Kuwahara… - The FEBS …, 2014 - Wiley Online Library
The mastoparan peptide is known as an inducer of the mitochondrial permeability transition.
Although mastoparan was suggested to interact with a proteinaceous target in mitochondria …

Biophysical Studies of TOAC Analogs of the Ctx(Ile21)-Ha Antimicrobial Peptide Using Liposomes

EF Vicente, LGM Basso, E Crusca Junior… - Brazilian Journal of …, 2022 - Springer
Antimicrobial peptides (AMP) are innate components of the defense system of many forms of
life, composing the first line of defense from invading pathogens. Among many AMPs …

Lipid-packing perturbation of model membranes by pH-responsive antimicrobial peptides

DS Alvares, TG Viegas, J Ruggiero Neto - Biophysical Reviews, 2017 - Springer
The indiscriminate use of conventional antibiotics is leading to an increase in the number of
resistant bacterial strains, motivating the search for new compounds to overcome this …

Interaction with lipopolysaccharide is key to efficacy of tryptophan-and arginine-rich α-melanocyte-stimulating hormone analogs against Gram-negative bacteria

K Tiwari, P Patel, AH Mondal… - Future …, 2024 - Taylor & Francis
Aim: In order to search for novel antibacterial therapeutics against Gram-negative bacteria,
the antibacterial efficacies and mechanism of action of tryptophan-and arginine-rich α …

[HTML][HTML] Interaction of Artepillin C with model membranes: effects of pH and ionic strength

WM Pazin, GCM Ruiz, ON de Oliveira Jr… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Artepillin C is the major constituent of green propolis, one of the most consumed products in
popular medicine owing to its therapeutic effects, including antitumor activity. Artepillin C …