Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides
important information about vascular health in a range of brain conditions and diseases …

Functional magnetic resonance imaging (fMRI) is a methodology for detecting dynamic
patterns of activity in the working human brain. Although the initial discoveries that led to …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Characterizing the effect of oxygen (O2) modulation on the brain may provide a better
understanding of several clinically relevant problems, including acute mountain sickness …

The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Velocity-selective inversion (VSI) based velocity-selective arterial spin labeling (VSASL) has
been developed to measure cerebral blood flow (CBF) with low susceptibility to the …

Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in
Alzheimer's disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is …

With age, many aspects of the brain structure undergo a pronounced decline, yet individuals
generally function well until advanced old age. There appear to be several compensatory …

Characterization of the influence of oxygen availability on brain metabolism is an essential
step toward a better understanding of brain energy homoeostasis and has obvious clinical …

Importance Disorders of brain metabolism are multiform in their mechanisms and
manifestations, many of which remain insufficiently understood and are thus similarly …