Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Adrenarche is the maturational increase in adrenal androgen production that normally
begins in early childhood. It results from changes in the secretory response to …

Background: Sugar-sweetened beverages are risk factors for type 2 diabetes; however, the
role of artificially sweetened beverages is unclear. Objective: The objective was to examine …

Several recent studies suggest that the timing of the onset of puberty in girls has become
earlier over the past 30 years, and there is strong evidence that the increasing rates of …

WNT4, a secreted protein that suppresses male sexual differentiation, is thought to repress
the biosynthesis of gonadal androgen in female mammals. An 18-year-old woman …

Adrenarche refers to the onset of dehydroepiandrosterone (DHEA) and DHEA‐sulphate
(DHEA‐S) production from the adrenal zona reticularis that can be detected at around 6 …

Context: Polycystic ovary syndrome (PCOS) appears to arise as a complex trait with
contributions from both heritable and nonheritable factors. Polygenic influences appear to …

Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used
medicinally and as a culinary spice. Objective: Medicinal use of ginger dates back to ancient …

With the rise in obesity worldwide, an important debate has developed as to whether excess
fat has a detrimental or protective effect on skeletal health in children and adults. Obese …