The medial frontal cortex and adjacent orbitofrontal cortex have been the focus of
investigations of decision-making, behavioral flexibility, and social behavior. We review …

The ability to adaptively regulate emotion is essential for mental and physical well-being.
How should we organize the myriad ways people attempt to regulate their emotions? We …

The prefrontal cortex (PFC) plays a critical role in the generation and regulation of emotion.
However, we lack an integrative framework for understanding how different emotion-related …

Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …

People with damage to the orbitofrontal cortex (OFC) have specific problems making
decisions, whereas their other cognitive functions are spared. Neurophysiological studies …

The well-replicated observation that many people maintain mental health despite exposure
to severe psychological or physical adversity has ignited interest in the mechanisms that …

Orbitofrontal cortex (OFC) has long been known to play an important role in decision
making. However, the exact nature of that role has remained elusive. Here, we propose a …

Economic choice behavior entails the computation and comparison of subjective values. A
central contribution of neuroeconomics has been to show that subjective values are …

Successful goal-directed behavior requires not only correct action selection, planning, and
execution but also the ability to flexibly adapt behavior when performance problems occur or …

Shifting between goal-directed and habitual actions allows for efficient and flexible decision
making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm …