UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …

Smoking has a profound impact on tumor immunity, and nicotine, which is the major
addictive component of smoke, is known to promote tumor progression despite being a non …

Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs).
Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most …

Among breast cancer patients who develop distant metastases, there is marked variability in
the clinical course, including metastasis pattern. Here, we present a retrospective study of …

Bone metastasis remains a major cause of mortality and morbidity in breast cancer.
Therefore, there is an urgent need to better select high-risk patients in order to adapt …

It is now accepted that breast cancer is not a single disease, but instead it is composed of a
spectrum of tumor subtypes with distinct cellular origins, somatic changes, and etiologies …

The ability to predict metastatic potential could be of great clinical importance, however, it is
uncertain if predicting metastasis to specific vital organs is feasible. As a first step in …

Metastases from different cancer types most often affect the lung parenchyma. Moreover, the
lungs are among the most frequent sites of growth of metastatic masses of …

Cell lines are widely-used models to study metastatic cancer although the extent to which
they recapitulate the disease in patients remains unknown. The recent accumulation of …