Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes

S Guo, D Gu, Y Yang, J Tian, X Chen - Journal of Nanobiotechnology, 2023 - Springer
Near-infrared (NIR) organic small molecule dyes (OSMDs) are effective photothermal agents
for photothermal therapy (PTT) due to their advantages of low cost and toxicity, good …

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

EB Pasquale - Nature Reviews Cancer, 2010 - nature.com
The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

S Beyaz, MD Mana, J Roper, D Kedrin, A Saadatpour… - Nature, 2016 - nature.com
Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function.
Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function …

Therapeutic targeting of EPH receptors and their ligands

AW Boyd, PF Bartlett, M Lackmann - Nature reviews Drug discovery, 2014 - nature.com
Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Wnt/catenin signaling in adult stem cell physiology and disease

A Ring, YM Kim, M Kahn - Stem Cell Reviews and Reports, 2014 - Springer
Wnt signaling plays an important role in development and disease. In this review we focus
on the role of the canonical Wnt signaling pathway in somatic stem cell biology and its …

The Wnt signaling pathway in cellular proliferation and differentiation: a tale of two coactivators

JL Teo, M Kahn - Advanced drug delivery reviews, 2010 - Elsevier
Wnt signaling pathways play divergent roles during development, normal homeostasis and
disease. The responses that result from the activation of the pathway control both …

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

JW Astin, J Batson, S Kadir, J Charlet, RA Persad… - Nature cell …, 2010 - nature.com
Metastatic cancer cells typically fail to halt migration on contact with non-cancer cells. This
invasiveness is in contrast to normal mesenchymal cells that retract on contact with another …

Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors

J You, R Zhang, C Xiong, M Zhong, M Melancon… - Cancer research, 2012 - AACR
Photothermal ablation (PTA) is an emerging technique that uses near-infrared (NIR) laser
light–generated heat to destroy tumor cells. However, complete tumor eradication by PTA …

Bone cell interactions through Eph/ephrin: bone modeling, remodeling and associated diseases

K Matsuo, N Otaki - Cell adhesion & migration, 2012 - Taylor & Francis
Bones cannot properly form or be maintained without cell-cell interactions through ephrin
ligands and Eph receptors. Cell culture analysis and evaluation of genetic mouse models …

Evolutionary plasticity of segmentation clock networks

AJ Krol, D Roellig, ML Dequéant, O Tassy… - …, 2011 - journals.biologists.com
The vertebral column is a conserved anatomical structure that defines the vertebrate phylum.
The periodic or segmental pattern of the vertebral column is established early in …