Radiolabelling of nanomaterials for medical imaging and therapy

J Pellico, PJ Gawne, RTM de Rosales - Chemical Society Reviews, 2021 - pubs.rsc.org
Nanomaterials offer unique physical, chemical and biological properties of interest for
medical imaging and therapy. Over the last two decades, there has been an increasing effort …

Rheumatoid arthritis microenvironment insights into treatment effect of nanomaterials

Y Zhu, T Zhao, M Liu, S Wang, S Liu, Y Yang, Y Yang… - Nano Today, 2022 - Elsevier
Rheumatoid arthritis (RA) causes a huge medical burden due to its high morbidity and
disability rate. Emerging evidences demonstrate that RA has a tumor-like microenvironment …

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

J Deprez, R Verbeke, S Meulewaeter, I Aernout… - Nature …, 2023 - nature.com
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well
documented. Liposomes are believed to largely transport drugs into inflamed joints by …

PET Imaging of Small Extracellular Vesicles via [89Zr]Zr(oxinate)4 Direct Radiolabeling

AA Khan, F Man, FN Faruqu, J Kim… - Bioconjugate …, 2022 - ACS Publications
Exosomes or small extracellular vesicles (sEVs) are increasingly gaining attention for their
potential as drug delivery systems and biomarkers of disease. Therefore, it is important to …

[HTML][HTML] Radiolabelling of extracellular vesicles for PET and SPECT imaging

AA Khan, RTM de Rosales - Nanotheranostics, 2021 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) such as exosomes and microvesicles have gained recent
attention as potential biomarkers of disease as well as nanomedicinal tools, but their …

Imaging inflammation with positron emission tomography

J Iking, M Staniszewska, L Kessler, JM Klose… - Biomedicines, 2021 - mdpi.com
The impact of inflammation on the outcome of many medical conditions such as
cardiovascular diseases, neurological disorders, infections, cancer, and autoimmune …

[HTML][HTML] A kit formulation for the preparation of [89Zr] Zr (oxinate) 4 for PET cell tracking: White blood cell labelling and comparison with [111In] In (oxinate) 3

F Man, AA Khan, A Carrascal-Minino, PJ Blower… - Nuclear medicine and …, 2020 - Elsevier
Background Advances in immunology and cell-based therapies are creating a need to track
individual cell types, such as immune cells (neutrophils, eosinophils, chimeric antigen …

Translational considerations in nanomedicine: the oncology perspective

AA Gabizon, RTM de Rosales, NM La-Beck - Advanced Drug Delivery …, 2020 - Elsevier
Nanoparticles can provide effective control of the release rate and tissue distribution of their
drug payload, leading to major pharmacokinetic and pharmacodynamic changes vis-à-vis …

In vivo real-time positron emission particle tracking (PEPT) and single particle PET

J Pellico, L Vass, A Carrascal-Miniño, F Man… - Nature …, 2024 - nature.com
Positron emission particle tracking (PEPT) enables 3D localization and tracking of single
positron-emitting radiolabelled particles with high spatiotemporal resolution. The translation …

Liposomal antagomiR‐155‐5p restores anti‐inflammatory macrophages and improves arthritis in preclinical models of rheumatoid arthritis

A Paoletti, B Ly, C Cailleau, F Gao… - Arthritis & …, 2024 - Wiley Online Library
Objective We previously reported an increased expression of microRNA‐155 (miR‐155) in
the blood monocytes of patients with rheumatoid arthritis (RA) that could be responsible for …