Systemic sclerosis is a rare acquired systemic disease characterised by a complex
pathogenesis and multi organ involvement. Every year the scientific world contributes to …

Idiopathic pulmonary fibrosis (IPF) and other forms of lung fibrosis are age-associated
diseases with increased deposition of mesenchymal collagen that promotes respiratory …

Abstract Purpose of Review Premature activation of aging-associated molecular
mechanisms is emerging as an important contributor to many diseases, including …

Objective Alpha-Klotho protein (α-Klotho) is an essential component of endocrine fibroblast
growth factor receptor complexes that governs multiple metabolic processes including aging …

Systemic sclerosis, a connective tissue disease, is characterized by thickening of the skin,
massive fibrosis of internal organs, vasculopathy, and immune system functioning …

Co-culture methods are widely used in tissue engineering to drive tissue formation with the
direct or indirect interaction of multiple cell types. Klotho is a novel biomarker involved in …

Methods Twenty-one SSc patients and 20 HC were enrolled. In SSc patients, peripheral
venous blood samples were collected at the first day before the autumn Iloprost infusion (t0) …

Klotho long recognized for its role in anti-aging, is potentially implicated in the pathogenesis
of rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Aging of the …

Background and aims Cirrhosis is associated with increased risk for osteoporosis and
osteopenia. This study aims to further investigate this relationship by examining if etiology …

Systemic sclerosis (SSc) is a multisystem autoimmune disease famous for tissue fibrosis [1].
It is well recognized that an altered equilibrium of pro-and anti-angiogenic activities in SSc …