Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …

Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …

Tetracyclines possess many properties considered ideal for antibiotic drugs, including
activity against Gram-positive and-negative pathogens, proven clinical safety, acceptable …

Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …

The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …

The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of
naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal …

Antibiotics have been used for the management of relatively few bacterial plant diseases
and are largely restricted to high-value fruit crops because of the expense involved …

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize mitochondrially encoded
membrane proteins that are critical for mitochondrial function. Here we present the complete …