Cancer is the second leading cause of death globally and remains a major economic and
social burden. Although our understanding of cancer at the molecular level continues to …

Plant breeding relies on the presence of genetic variation, as well as on the ability to break
or stabilize genetic linkages between traits. The development of the genome-editing tool …

Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …

Most genome editing analyses to date are based on quantifying small insertions and
deletions. Here, we show that CRISPR-Cas9 genome editing can induce large gene …

Fusion oncogenes (FOs) are common in many cancer types and are powerful drivers of
tumor development. Because their expression is exclusive to cancer cells and their …

TERRAs are long non-coding RNAs generated from the telomeres. Lack of TERRA knockout
models has hampered understanding TERRAs' functions. We recently identified …

Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing
EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic …

Purpose The high percentage of patients carrying germline mutations makes
pheochromocytomas/paragangliomas the most heritable of all tumors. However, there are …

Chromosomal translocations are associated with several tumor types, including
hematopoietic malignancies, sarcomas, and solid tumors of epithelial origin, due to their …

Enhancing the intracellular delivery and performance of RNA-guided CRISPR-Cas9
nucleases (RGNs) remains in demand. Here, we show that nuclear translocation of …