High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …

Organelles are critical structures in mediating the assembly and activation of
inflammasomes in mammalian cells, resulting in inflammation and cell death. Assembly of …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Inflammation is triggered by a repertoire of receptors detecting infections and damages.
Some of these receptors directly bind microbial ligands, while others recognize endogenous …

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Acute respiratory distress syndrome (ARDS), a devastating complication of numerous
conditions, is often associated with high mortality. It is well known that endothelial cell (EC) …

Trauma remains a leading cause of death worldwide. Hemorrhagic shock and direct injury to
vital organs are responsible for early mortality whereas most delayed deaths are secondary …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

Inflammaging refers to a low-grade pro-inflammatory phenotype which accompanies aging
in mammals. The aging process is associated with a decline in autophagic capacity which …