Hemoglobin: structure, function and allostery
This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …
[HTML][HTML] Turmeric: potential health benefits
K Singletary - Nutrition Today, 2020 - journals.lww.com
For centuries, Curcuma longa (turmeric) was used as a spice in Asian cuisine and as a
medicinal herb for treatment of inflammation, pain, wound healing, and digestive disorders …
medicinal herb for treatment of inflammation, pain, wound healing, and digestive disorders …
[HTML][HTML] Vanilla: potential health benefits
KW Singletary - Nutrition Today, 2020 - journals.lww.com
The vanilla bean, obtained from Vanilla planifolia and Vanilla tahitensis, members of the
Orchidaceae family, is the source of vanilla extract, one of the most desired and widely used …
Orchidaceae family, is the source of vanilla extract, one of the most desired and widely used …
Red blood cells as therapeutic target to treat sickle cell disease
S Bhatt, DA Argueta, K Gupta… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Sickle cell disease (SCD) is the most common inherited diathesis affecting
mostly underserved populations globally. SCD is characterized by chronic pain and fatigue …
mostly underserved populations globally. SCD is characterized by chronic pain and fatigue …
VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions
Sickle cell disease (SCD) results from a hemoglobin (Hb) mutation βGlu6→ βVal6 that
changes normal Hb (HbA) into sickle Hb (HbS). Under hypoxia, HbS polymerizes into rigid …
changes normal Hb (HbA) into sickle Hb (HbS). Under hypoxia, HbS polymerizes into rigid …
Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property
PP Pagare, A Rastegar, O Abdulmalik… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Sickle cell disease (SCD) is a debilitating inherited disorder that affects millions
worldwide. Four novel SCD therapeutics have been approved, including the hemoglobin …
worldwide. Four novel SCD therapeutics have been approved, including the hemoglobin …
Design, synthesis, and investigation of novel nitric oxide (NO)-releasing aromatic aldehydes as drug candidates for the treatment of sickle cell disease
Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing
deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in …
deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in …
Targeted modification of furan‐2‐carboxaldehydes into Michael acceptor analogs yielded long‐acting hemoglobin modulators with dual antisickling activities
Sickle cell disease (SCD) is the most common genetic disorder, affecting millions of people
worldwide. Aromatic aldehydes, which increase the oxygen affinity of human hemoglobin to …
worldwide. Aromatic aldehydes, which increase the oxygen affinity of human hemoglobin to …
Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin
NA Enakaya, A Jefferson… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus Sickle cell disease (SCD) is an inherited blood disorder caused by a point
mutation in hemoglobin (Hb), the protein in the red blood cell (RBC) responsible for the …
mutation in hemoglobin (Hb), the protein in the red blood cell (RBC) responsible for the …
Advances in sickle cell disease treatments
AR Pavan, JL Dos Santos - Current Medicinal Chemistry, 2021 - benthamdirect.com
Sickle Cell Disease (SCD) is an inherited disorder of red blood cells that is caused by a
single mutation in the β-globin gene. The disease, which afflicts millions of patients …
single mutation in the β-globin gene. The disease, which afflicts millions of patients …